Summary
This study introduces a non-invasive bimodal approach that combines light backscattering spectroscopy and quantitative ultrasound techniques for characterizing bone tumor types, specifically chondrosarcomas and osteosarcomas.
The study used animal models with two different cell lines to induce osteosarcoma growth and conducted histological analyses for reference. The results demonstrated significant differences in ultrasound parameters and light reflectance profiles between the two tumor types and even variations within the same type of osteosarcoma, highlighting the sensitivity of the techniques in probing tissue properties. Additionally, the approach successfully estimated morphological parameters at the cellular and nuclear scales, making it a promising tool for tumor characterization.
