This study evaluates the efficacy of CEUS-BI-RADS compared to MRI-BI-RADS in diagnosing breast lesions with calcifications. Conducted on 52 lesions across 51 patients, the research demonstrates CEUS-BI-RADS’s superior diagnostic accuracy, specificity, and efficiency. CEUS-BI-RADS integrates the CEUS 5-point score system with traditional ultrasound-BI-RADS, redefining lesion classification and improving differentiation between benign and malignant calcifications. The results reveal that CEUS-BI-RADS achieves a sensitivity of 95%, a specificity of 96.8%, and an accuracy of 96.1%, surpassing MRI and ultrasound-BI-RADS in diagnostic performance. The study highlights the potential of CEUS-BI-RADS to reduce unnecessary biopsies and improve patient outcomes. CEUS, using microbubble contrast agents, addresses the limitations of conventional ultrasound by enhancing the visualization of microcirculation around calcifications. Compared to MRI, CEUS provides typical enhancement patterns, aiding in the precise evaluation of breast lesions. While MRI offers high sensitivity, its lower specificity often leads to false positives and unnecessary biopsies. CEUS-BI-RADS overcomes these challenges, delivering reliable, efficient, and accurate diagnoses, making it a valuable tool for breast cancer detection. This research supports CEUS-BI-RADS as a promising alternative to MRI in the differentiation of breast lesions with calcifications, providing a significant advancement in breast imaging. Early detection of breast cancer remains critical, and CEUS-BI-RADS represents an important step forward in enhancing diagnostic precision and reducing invasive procedures.