Summary
Focused ultrasound (FUS) combined with microbubble injection for blood-brain barrier (BBB) opening can serve as a form of immunotherapy for neurodegenerative disorders. In a mouse model, this study utilized single-cell sequencing to investigate the distinct responses of microglia and central nervous system-associated macrophages (CAMs) to FUS-mediated BBB opening.
Results indicate that this treatment remodels the immune landscape by recruiting CAMs, increasing the proliferation of microglia, and enlarging the population size of disease-associated microglia. These changes in the immune response highlight the potential of FUS BBB opening as an approach to treat neurodegenerative disorders.
