Summary
In this study, researchers aimed to enhance tumor perfusion and chemotherapeutic drug accumulation using diagnostic ultrasound and microbubbles and to investigate the impact on reactive oxygen species. VX2-bearing rabbits were divided into three groups: doxorubicin with high pulse repetition frequency ultrasound (1000 Hz), low pulse repetition frequency ultrasound (500 Hz), and a control group.
Tumors were treated with a modified diagnostic ultrasound, microbubbles, and doxorubicin. Results showed that tumor perfusion was associated with drug concentration, and after ultrasound and microbubbles treatment, tumor perfusion increased, leading to enhanced doxorubicin accumulation.
The concentration of doxorubicin was significantly higher in the treated groups compared to the control, and reactive oxygen species also improved after treatment. The study suggests that diagnostic ultrasound and free microbubbles therapy can noninvasively and effectively improve tumor perfusion and enhance therapeutic efficacy.
