This case report details the management of a 71-year-old male with infected necrotizing pancreatitis (INP) following an episode of acute pancreatitis. Initially treated conservatively, the patient developed signs of sepsis and was found to have large gas-containing fluid collections on CT scans. He underwent percutaneous catheter drainage (PCD), which revealed Meropenem-resistant E. coli, prompting a change in antibiotic therapy. Follow-up imaging showed resolution of fluid collections, and the patient recovered without the need for laparotomy. The report emphasizes the effectiveness and safety of PCD as part of a minimally invasive approach to managing INP, highlighting its advantages over traditional surgical methods.