This study aimed to compare various ultrasound parameters for diagnosing carpal tunnel syndrome (CTS) in 80 patients, using nerve conduction study (NCS) as the gold standard. The parameters evaluated included cross-sectional area (CSA), delta CSA, wrist forearm ratio (WFR), palmer bowing (PB), flattening ratio (FR), flexor retinaculum thickness (FT), and median nerve echogenicity and vascularity. Delta CSA demonstrated the highest diagnostic accuracy at 91.25%, followed by CSAc and WFR. ROC analysis indicated delta CSA as the best parameter with an area under the curve of 97.1%. The study suggests that delta CSA can serve as an effective alternative to NCS for diagnosing CTS, although further research is necessary to confirm these results.