To assess the role of lung ultrasound (LUS) in predicting bronchopulmonary dysplasia (BPD) at days 7 and 14 of life in preterm infants, a prospective cohort study was conducted with 95 preterm infants ≤ 34 weeks. LUS was performed on days 7 and 14 of life. Infants who developed BPD showed significantly higher LUS scores at both time points. A LUS score > 8 at day 7 had 83.33% sensitivity and 60.87% specificity, and at day 14, it had 76.39% sensitivity and 82.61% specificity. Multivariate analysis identified several factors associated with BPD, including gestational age ≤ 30 weeks, LUS score > 8 at day 7, low platelet count, low segment neutrophils, and elevated CRP. These findings indicate that LUS can independently predict BPD and its severity in preterm infants.