Myopericytomas (MPs) are rare benign tumors commonly found in young women, with fewer than 200 cases reported, often leading to misdiagnosis. Ultrasound is a valuable tool for diagnosing and managing these tumors. This report discusses a 58-year-old woman with a history of vulvar melanoma and inguinal lymph node involvement. During proton therapy and follow-up, a subcutaneous nodular lesion appeared on her right wrist. Ultrasound imaging showed a well-defined, hypoechoic, round dermal-subcutaneous lesion with posterior acoustic enhancement and intense peripheral vascularity, suggestive of a vascular tumor. Spectral Doppler showed a biphasic waveform. Shear wave elastography indicated a median value of 3.5 m/s and 31.71 kPa. The lesion was excised, and histopathological examination confirmed the diagnosis of MP, with immunohistochemical staining positive for smooth muscle actin, caldesmon, and CD34.
