A new article published in the BIO Integration journal highlights the crucial role of the tumor microenvironment (TME) in tumor development, metastasis, and recurrence. The complex and chaotic structure of the TME not only hinders drug delivery but also fosters resistance to immunotherapy. The article explores how breaking these physical barriers can optimize existing tumor treatments. It discusses how physical stimulations like ionizing radiation, light, electricity, magnetic fields, and ultrasound can modulate the TME by altering tumor vasculature, remodeling the extracellular matrix, and activating immune responses. These stimulations, when used as adjuvants, enhance the efficacy of chemotherapy, immunotherapy, and other cancer treatments. The authors analyze the structural characteristics of the TME and the synergistic effects of these physical interventions.
PHYSICAL MODULATION OF THE TUMOR MICROENVIRONMENT TO ENHANCE CANCER THERAPY
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