University of Queensland (UQ) researchers have discovered that ultrasound alone, without targeting amyloid plaques, can significantly improve cognitive function in neurodegenerative disorders, challenging a prevailing approach in Alzheimer’s research. Traditionally, amyloid plaques—protein clumps in the brain that hinder cell communication and are linked to memory loss in Alzheimer’s disease—have been a primary focus in treatments aimed at improving cognition. Previous studies have used ultrasound with microbubbles to open the blood-brain barrier, activating microglia cells that clear these plaques. However, Dr. Gerhard Leinenga and Professor Jürgen Götz of UQ’s Queensland Brain Institute found that using ultrasound alone on mouse models led to notable memory enhancement, suggesting that clearing plaques may not be essential for cognitive improvement.
Dr. Leinenga explained that ultrasound alone can stimulate the brain directly, leading to long-term cognitive changes. The ultrasound treatment appeared to increase plasticity and strengthen brain networks, potentially boosting the brain’s resilience to the effects of plaques without removing them. Professor Götz added that the effectiveness of the ultrasound treatment varied with the frequency used, with higher frequencies delivering better results compared to those used in current clinical trials for Alzheimer’s.
This study represents a promising development in non-invasive treatment strategies for Alzheimer’s and other neurodegenerative conditions, supporting a more personalized approach to therapy. The findings will inform Professor Götz’s ongoing safety trial on ultrasound therapy for Alzheimer’s, aiming to tailor treatment frequencies and protocols to maximize cognitive improvement. Dr. Leinenga highlighted the importance of understanding ultrasound’s mechanisms, as it opens the door to personalized, effective treatment options for patients with neurodegenerative disorders. The research has been published in Molecular Psychiatry, marking an important step toward innovative therapies that could significantly impact patient outcomes in the field of neurodegenerative disease.
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