A recent study published in Scientific Reports investigated the impact of low-dose aspirin (LDA) on adverse pregnancy outcomes in twin pregnancies conceived through assisted reproductive technology (ART). Conducted in China, this retrospective cohort study analyzed data from 510 women with twin pregnancies between 2016 and 2021. The study found that while LDA effectively reduced the risk of preeclampsia (PE) without increasing the likelihood of significant bleeding complications, it had limited effectiveness in preventing other complications specific to twin pregnancies. The protective effect was particularly evident in mothers under 30 years of age.
Participants were divided into two groups: one receiving 100 mg/day of aspirin between 10 and 16 weeks of gestation and a control group with no aspirin use. Researchers analyzed maternal and neonatal outcomes, including gestational age at delivery, hypertensive disorders, gestational diabetes, premature rupture of membranes, and secondary complications like small-for-gestational-age (SGA) neonates and twin-to-twin transfusion syndrome. Results showed a lower PE incidence in the aspirin group, although the rate of overall hypertensive disorders was slightly higher. Importantly, aspirin use did not influence the gestational age at delivery, increase postpartum hemorrhage risk, or significantly affect neonatal outcomes, including NICU admissions.
Interestingly, cesarean delivery rates were lower among aspirin users, and age-stratified data revealed a more pronounced protective effect in younger mothers. Despite the growing use of aspirin in ART twin pregnancies, its effectiveness remains context-dependent, underscoring the need for individualized assessment by healthcare providers. These findings highlight the potential role of LDA in reducing PE risk in ART twin pregnancies while maintaining safety. However, further research is needed to explore its broader impact on twin-specific complications. The study provides valuable insights to guide clinical decisions, emphasizing the importance of early intervention in improving maternal and neonatal outcomes.
