Melanoma is a highly aggressive cancer, with uveal melanoma being the most common primary intraocular malignancy in adults, accounting for 3-5% of all melanomas. While cutaneous melanoma typically metastasizes to various sites, uveal melanoma primarily spreads to the liver, with liver metastases detected in about 87% of metastatic uveal melanoma cases. These liver metastases are often asymptomatic until advanced stages, making early detection challenging. This case report describes a patient with a large liver mass, where neither contrast-enhanced CT nor MRI could establish a definitive diagnosis. The final diagnosis of uveal melanoma metastasis was confirmed through an ultrasound-guided biopsy. The report also reviews the literature on imaging follow-up for melanoma patients.
