A prospective study was conducted to assess the safety and effectiveness of percutaneous release procedures under ultrasound guidance using Sono-Instruments® for treating carpal tunnel syndrome (CTS) and trigger finger (TF). The study included 30 patients, divided equally into two groups: 15 for CTS and 15 for TF. Primary outcomes were related to surgical performance, including visibility, ease of use, satisfaction, and procedure duration, along with patient-reported outcomes such as pain, activity limitations, return to work, and functional scores. Secondary outcomes focused on complications, with patients monitored for two months post-operatively. In the CTS group, the average patient age was 58.7 years. All patients successfully underwent the percutaneous release of the transverse carpal ligament, with excellent device performance and no adverse events reported. At one week post-procedure, all patients could wash their hands, 80% performed daily activities independently, and 80% returned to work. By two months, all patients had resumed all activities, although 53.3% still experienced pillar pain. In the TF group, with an average age of 57.9 years, percutaneous release of the A1 annular pulley was also completed successfully in all cases, again with excellent device performance and no adverse events. One week post-procedure, all patients could wash their hands, 93.3% performed daily activities independently, and 75% returned to work. By two months, all patients in this group resumed all activities. The DASH score significantly improved for both groups at two months post-operatively (p < 0.001), demonstrating that percutaneous sono-guided release using Sono-Instruments® is safe and effective, leading to quick functional recovery.