The 2024 Guideline Amendment from the American Urological Association updates recommendations for evaluating and managing male infertility. Based on a review of 4,093 new abstracts, the panel included 22 studies that informed their evidence-based statements. Key insights include revised thresholds for Y-chromosome microdeletion testing, indications for pelvic MRI in infertile males, and guidance on using testicular sperm in nonazoospermic men. Ongoing review is essential as diagnostic and treatment options evolve.