Summary
This study explores the use of transcranial low-intensity focused ultrasound (LIFU) as a potential method to influence the blood-brain barrier (BBB) and enhance drug delivery to the brain. In in vivo rat experiments, LIFU was applied without the use of intravenous microbubbles.
The results indicated that LIFU exposure did not seem to directly open the BBB but rather increased the transcytosis of a dextran tracer. Additionally, the study found increased localization of stem cell-derived exosomes in the right hippocampus following targeted LIFU exposure, suggesting the potential for enhanced drug delivery to specific brain regions using this technique.
