Introduction
High-frequency hybrid ultrasound imaging, operating at 55 MHz, revolutionizes vascular tissue characterization and atherosclerosis diagnosis in mice. This advanced imaging method integrates novel parameters like time variance, time entropy, and wavelet backscatter for unparalleled precision in detecting and analyzing atherosclerotic plaques. Using state-of-the-art ultrasound technology, including single-element transducers and commercial array systems, the study highlights exceptional spatial resolution (≤40 µm), enabling accurate evaluation of plaque composition.
Cardiovascular Diagnostics
Experimental results demonstrate the technique’s efficacy in differentiating between normal and diseased vascular tissues, with histology and optical imaging providing strong validation. By combining RF data analysis in time, frequency, and wavelet domains, this innovative approach bridges the gap in noninvasive cardiovascular diagnostics. Offering a promising alternative to invasive techniques, this method can be adapted to commercial ultrasound systems, enhancing its potential for clinical applications in cardiovascular disease management.
